The 500 Superfast was presented at the 1964 Geneva Salon, and would have a limited production run into 1966. It would also be the last low volume production coupé produced by Ferrari, in a series that had started with the America and Superamerica of the fifties and early sixties. As the series production car output increased in number and uniformity, the tooling necessary for small series runs was becoming less viable, despite the greater sales price. A total of thirty-six examples were produced in the chassis number range 05951SF to 08897SF, whilst a one-off 330 GT 2+2 (chassis 06267) was produced with a Superfast-style body for HRH Prince Bernhard of The Netherlands. Clients for this exclusive form of transportation, which cost as much as two Rolls Royce when new, included the Shah of Iran (who bought two within four months in 1965) and the British actor Peter Sellers.

The body was designed by Pininfarina, and bore striking similarities to the 400 SA Coupé Aerodinamico. It had a large, shallow oval radiator grille opening, with open headlights in deep wing recesses as standard, although two examples received Plexiglass covers.
A long sweeping bonnet ran into an airy cabin section with slim roof pillars, from which the rear screen flowed into the boot line, terminating in a neat shallow oval Kamm tail. The tail lights were horizontal, bullet-shaped assemblies with three individual circular lenses to each unit, unique to this model. Wrap-around chrome-plated quarter bumpers were fitted front and rear: those at the front with shallow recesses for the circular side/turn lights (apart from the first car in the series which had shallow elliptical flush lights above the bumper). Early examples in the series had 11-slot engine bay exhaust vents in the front wings, succeeded later by a triple louvre assembly, as had happened on the 330 GT 2+2 and 275 GTS models. Despite the change to alloy wheels as standard to Ferrari road cars of the period, the 500 Superfast was fitted with 7L x 15” Borrani wire wheels throughout the production run. The bodies were mounted on a 2650 mm wheel base chassis that had the factory reference number 578, and all were numbered in the odd chassis number road car sequence carrying an ‘SF’ suffix. This was the last series of Ferrari cars to carry chassis number suffix letters. The chassis and its ancillary components were very similar in construction to that of the concurrent 330 GT 2+2 model, with a tubular steel frame, independent front suspension, rigid rear axle with leaf springs and telescopic shock absorbers, four wheel disc brakes, with separate front and rear hydraulic circuits, and either left- or right-hand drive: eight examples being produced in the latter form.